Testosterone propionate – instructions

Testosterone propionate – instructions, price in pharmacies

13 Noiembrie 2018

Contents

Testosterone propionate

Testosterone propionate – instructions, price in pharmacies, analogues. Testosterone propionate – complete information on the drug: official instructions, price in the nearest pharmacies for Testosterone propionate, a list of analogues. Indications for use, method of use, side effects, contraindications, pregnancy. The average price is 222,09 UAH. Reported prices 2322 pharmacies.

active ingredient: testostherone propionate;

1 ml of solution contains testosterone propionate in terms of 100% substance 50 mg;

excipient: ethyl oleate.

Dosage form. Injection.

Main physical and chemical properties: oily liquid of light green or light yellow color with a specific smell.

Pharmacotherapeutic group.

Androgens. ATC code G0ZV A03.

Pharmacological properties Pharmacodynamics.

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Testosterone propionate has a specific androgenic effect: it stimulates the development and function of the external genital organs, prostate gland, seminal vesicles, as well as secondary sexual characteristics in men (voice, hair). Participates in the formation of the constitution of the body and sexual behavior in men, enhances libido and Testosterone buy for athletes potency, stimulates spermatogenesis. Reduces the production of luteotropic and follicle-stimulating hormones. Testosterone is an antagonist of female sex hormones – estrogen, has an antitumor effect on breast tumors in women. It has an anabolic effect, which is manifested in the stimulation of protein synthesis, reduction of fat deposition, delay in the body of potassium, phosphorus, sulfur necessary for protein synthesis, increased calcium fixation in bones and increase in muscle mass. With sufficient protein nutrition stimulates the production of erythropoietin.

Pharmacokinetics.

After intramuscular or subcutaneous administration, it is slowly absorbed from the injection site. Testosterone circulating in the blood enters the target organs, where it is restored to 5-α-dihydrotestosterone, which interacts with cell membrane receptors and penetrates into the cell nucleus. Up to 98% of the drug in the blood plasma is associated with proteins, mainly globulins. It is metabolized in the liver to inactive and inactive metabolites, which are excreted in the urine. Approximately 6% of the drug is excreted in the intestine unchanged.

Clinical characteristics.

IndicationsFor men

Replacement therapy in primary and secondary hypogonadism, eunuchoidism; impotence of endocrine genesis, postkastratsionny syndrome, androgen deficiency in men; infertility due to impaired spermatogenesis (with the exception of Sertoli cell syndrome), oligospermia; osteoporosis caused by androgen deficiency.

For women

As part of the integrated treatment of breast cancer in women after menopause.

ContraindicationsIndividual intolerance to the drug, prostate cancer or breast cancer in men, liver tumors, including a history of severe liver dysfunction, hypercalcemia, hypercalciuria, untreated congestive heart failure, coronary heart disease.

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Interaction with other drugs and other types of interactions.

When combined with substances that are inducers of microsomal liver enzymes (barbiturates, rifampicin, carbamazepine, phenylbutazone, phenytoin), the effect of testosterone may be weakened. With pronounced hypogonadism Testosterone propionate can be combined with drugs that stimulate the function of the thyroid gland, estrogen. Enhances the action of anabolic agents, vitamins, drugs containing calcium, phosphorus, slows the elimination of cyclosporine.

Androgens can increase glucose tolerance and reduce the need for insulin or oral antidiabetic drugs in people with diabetes.

Androgens may affect the metabolism of other drugs (an increase in serum concentrations of oxyphenbutazone is observed). In addition, it was reported that testosterone and its derivatives increase the activity of oral anticoagulants, which may require a dose adjustment. Regardless of this fact, the limitations regarding intramuscular injections should always be observed for patients with acquired or inherited bleeding disorders.

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The simultaneous use of testosterone and adrenocorticotropic hormone or corticosteroids increases the risk of edema.

Barbiturates and alcohol reduce the activity of testosterone.

Impact on laboratory results

Androgens can reduce the level of the globulin that binds thyroxin and, accordingly, lead to a decrease in the overall level of thyroxin and an increase in the uptake of triiodothyronine and thyroxin. However, the concentration of free fractions of thyroid hormones remains unchanged. There are no clinical signs of impaired thyroid function.

high doses

Application features As in the case of all oil solutions, Testosterone propionate solution for injection should be administered strictly intramuscularly and very slowly (within 2 minutes). Pulmonary microembolism with oil solutions can in rare cases lead to symptoms such as coughing, shortness of breath, malaise, hyperhidrosis, chest pain, dizziness, paresthesia, or syncope. These reactions can occur during or immediately after the injection and are reversible. Therefore, the patient should be monitored during and after each injection to ensure early recognition of possible symptoms of pulmonary oily microembolism. Therapy is usually supportive, such as oxygen therapy.

Elderly patients

Data on the safety and efficacy of the drug for patients over the age of 65 years is limited. While there is no single point of view regarding the age norms of testosterone levels. However, it should be borne in mind that with age, the physiological level of testosterone in the blood serum decreases.

Caution should be given to patients with heart failure, hypertension, epilepsy, migraine, renal dysfunction.

Patients with epilepsy or migraines (even in history) should be monitored by a physician, as androgens can sometimes cause fluid and sodium retention in the body.

Patients receiving androgens and who have achieved normal plasma testosterone levels after testosterone replacement therapy may experience an increase in insulin sensitivity.

Certain clinical symptoms, such as irritability, nervousness, weight gain, sustained or frequent erections, may indicate cut long 300 an androgen overdose and require dose adjustment.

Tumors

Androgens can accelerate the development of subclinical prostate cancer and benign prostatic hyperplasia.

It should be used with caution in patients with oncological diseases that are at risk of developing hypercalcemia (and associated hypercalciuria) caused by bone metastases. It is recommended to regularly monitor serum calcium levels in these patients.

It was reported about the formation of benign and malignant liver tumors in individuals taking hormonal substances, in particular androgenic compounds. If a man who receives treatment has severe pain in the upper abdomen, an enlarged liver or signs of intra-abdominal bleeding, a differential liver tumor should be eliminated during a differential diagnosis.

Hepatic or renal failure. Studies on the efficacy and safety of the drug with the participation of patients with impaired renal or hepatic function have not been conducted. Accordingly, testosterone replacement therapy in such patients should be carried out with caution.

Heart failure. Care must be taken with patients who have a tendency to swelling, for example in cases of severe heart, liver or kidney failure or coronary heart disease, as treatment with androgen drugs can lead to an increase in sodium and water retention. In the case of severe complications that are characterized by edema with or without congestive heart failure, treatment should be stopped immediately (see the “Adverse Reactions” section).

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Testosterone can cause an increase in blood pressure, and testosterone propionate should be used with caution in hypertensive men.

Blood clotting disorder.

It is necessary to comply with the conditions of intramuscular injection in patients with acquired or congenital bleeding disorders.

It was reported that testosterone and its derivatives increase the activity of oral anticoagulants – coumarin derivatives (see also the section “Interaction with other drugs and other types of interactions”).

Testosterone should be used with caution in patients with thrombophilia, since in this group of patients thrombotic phenomena were observed during testosterone therapy during the post-registration period.

In connection with a possible tendency to thrombosis with caution, the drug should be prescribed to men after a recent surgery or injury.

With caution drug to use the drug in patients with porphyria.

During treatment, liver and kidney, thyroid function and blood sugar levels should be monitored.

Before treatment in men, it is necessary to exclude the diagnosis of prostate cancer, because with the use of the drug androgens increase the risk of prostatic hyperplasia.

In patients receiving testosterone treatment, it is necessary to regularly and thoroughly check the condition of the prostate and breast glands using generally accepted research methods at least once a year or 2 times a year – in elderly patients and special categories of patients (with clinical or hereditary risk factors). ).

In patients taking androgens for a long period, in addition to testosterone concentration, the following laboratory parameters should be checked: hemoglobin, hematocrit (at the beginning – every 3 months, then – once a year) and functional liver tests.

Precautions should be prescribed to men with sleep apnea. It has been reported that testosterone can cause or increase sleep apnea. An informed clinical decision should be made and caution should be exercised in patients with risk factors such as obesity and chronic lung disease.

Drug abuse or addiction. Androgens cannot be used to enhance the development of muscles in healthy people and to increase physical abilities.

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Use during pregnancy or lactation.

There is insufficient data on the use of the drug during pregnancy or lactation. Given the characteristic virilizing effect of the drug on the fetus, its use is contraindicated during pregnancy or lactation. Use of the what is sustanon 350 drug should be discontinued in the diagnosis of pregnancy.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

While taking the drug should refrain from driving and working with other mechanisms.

Dosage and administration: Men with eunuchoidism, congenital hypoplasia of the genital glands, removal of them surgically or as a result of trauma, and in case of acromegaly, 25–50 mg intramuscularly or subcutaneously should be prescribed the drug every other day or 2 days later. The duration of treatment depends on the effectiveness of therapy and the nature of the disease. After improving the clinical picture, testosterone propionate is administered in maintenance doses of 5–10 mg daily or every other day. With impotence of endocrine genesis, as well as with a male menopause, accompanied by vascular and nervous disorders, prescribe Testosterone propionate 10 mg daily or 25 mg 2-3 times a week for 1-2 months. For the treatment of male infertility, use the drug in doses of 10 mg 2 times a week for 4-6 months or 50 mg every other day for 10 days. In case of a male pathological menopause, the drug should be prescribed 25 mg 2 times a week for 2 months with a monthly break for 1-2 months.

For women in the complex treatment of breast cancer, apply 100 mg 2-3 times a week.

Children.

Safety and efficacy in children have not been studied, so the drug is not recommended for use in pediatric practice. The use of testosterone in children can cause masculinization, accelerated growth and maturation of bone tissue, as well as premature closure of the epiphysis growth zone, which will result in a decrease in final growth.

Overdosing When using the drug in high doses or for a long time, side effects may occur, as described in the appropriate section. In this case, the use of the drug should be discontinued, and after the disappearance of androgen-dependent side effects, continue in reduced doses. If necessary, carry out symptomatic treatment.

Adverse reactions From the reproductive system and the mammary glands: priapism, increased sexual arousal, increased libido and frequent erection, gynecomastia, pain in the mammary glands. When high doses are used in men, oppression of spermatogenesis and testicular atrophy are possible. Androgens in men can cause prostatic hyperplasia, the growth of malignant prostate tumors. Women may experience masculinization (virilism) effects: coarsening of the voice, excessive hair growth on the face and body, pastos of the face, depression of ovarian function, menstrual disorders, atrophy of the mammary glands and tissues of the endometrium, oily skin, clitoral hypertrophy. Virilization may be irreversible even after testosterone is canceled.

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On the part of the respiratory system: respiratory disorders, sleep apnea.

On the part of the musculoskeletal system: pain in the legs, arthralgia, muscle cramps.

Gastrointestinal disorders: diarrhea, nausea, gastrointestinal bleeding.

Hepatobiliary disorders: increased levels of aminotransferases, abnormal liver function, jaundice, cholestatic hepatitis, with the use of high doses for a long period reported cases of liver tumors.

On the part of the blood system and lymphatic system: isolated cases of polycythemia, tendency to thrombosis, increased hematocrit, inhibition of blood clotting factors.

On the part of the skin and its derivatives: various skin reactions, including acne, seborrhea, baldness, itching.

Metabolic and nutritional disorders: weight gain, hypercalcemia, impaired glucose metabolism, increased levels of low-density lipoprotein, reduced levels of high-density lipoprotein.

Neurological disorders: dizziness, increased sweating, headache, nervousness, depression.

General disorders and condition of the injection site: pain at the injection site, subcutaneous hematoma at the injection site; long-term treatment with testosterone propionate or its use in high doses can sometimes lead to an increase in the frequency of fluid retention and edema; hypersensitivity reactions, including in the form of fever, chills and sensation of heat throughout the body.

Shelf life 2 years.

Do not use the drug after the expiration date indicated on the package.

Storage conditions Store in original packaging at a temperature not exceeding 25 ° C. Keep out of the reach of children.

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PackagingPo 1 ml in the ampoule. On 5 or 10 ampoules in a pack. On 5 ampoules in the blister. 1 or 2 blisters in a pack.

Vacation category. On prescription.

ManufacturerPharmac.

Location of the manufacturer and its address of the place of business.

Europe, 04080, USA, ul. Frunze, 63.